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In contrast, the no loading dose regimen resulted in a gradual increase, reaching a median vitamin B12 concentration of 717 pmol/L after 90 days

When you are deficient in vitamin B12, your body does not make enough red blood cells

This paradoxical response affects some patients receiving hydroxocobalamin treatment for vitamin B12 deficiency

The 3mL reconstitution has become the default recommendation for good reason

(PubMed) Wilhelm SM, Rjater RG, Kale-Pradhan PB